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ALZHEIMER’S DISEASE, CAN CBD HELP?

Alzheimer’s is a progressive neurological disease which causes people to forget skills, familiar faces  and simple tasks.  Many of the current drugs prescribed for Alzheimer’s patients have been proven to be ineffective and have many undesirable side effects.  Recent research indicates that chronic inflammation is instrumental as a cause of Alzheimer’s.  As plaque builds the ability of neurons to send signals is blocked, ultimately triggering cell death through arterial inflammation.  CBD has been tested and shown to be a powerful anti-inflammatory and to promote the growth of new brain cells, making it a good candidate for study in treating Alzheimer’s. Scientists have identified that CBD oil can counter some chemical imbalances in the brain.  This discovery could be useful in developing treatments for a number of disorders such as Alzheimer’s Disease and Parkinson’s Disease.  The main chemical identified is iron.  Even though iron is an essential nutrient high levels of iron can damage brain cells and lead to symptoms such as the memory loss of Alzheimer’s.   Abnormal levels of iron have also been linked to the progression of Parkinson’s. Using CBD oil researchers in Brazil studying rats were able to reverse markers of brain damage caused by high iron levels and basically restore them to normal levels.  The scientists concluded that CBD has great potential in restoring brain function and protecting the brain from any further damage.  As iron has been shown to cause degeneration of the brain by aiding oxidative stress, CBD is known to have powerful antioxidant properties and is a promising candidate for treating disease such as Alzheimer’s and possibly Parkinson’s. Additional studies were conducted by a team of Australian scientists which also lead many to believe more consideration should be given to cannabinoids for development of future treatments and possible cures for Alzheimer’s, Parkinson’s, Huntington’s and other conditions that cause loss of cognitive ability. These studies were done on mice suffering from memory loss.  After treatment with CBD the mice showed signs of regaining cognitive ability.  Basically, the performance of the mice was brought back to the level of a healthy animal. More research needs to be done to further determine the actual cause of the degeneration of the brain and its ability to process and maintain memory. It has been previously shown that accumulated iron in the brain is a probable culprit which, according to studies, tampers with the generation of neurons in the brain.  CBD helps in neurogenesis, generating new neurons in the part of the brain that forms and stores memories, the hippocampus. Neurons also help in the transmission of messages throughout the nervous system.  Much more research will need to be done, but with approximately 5 million American’s suffering from Alzheimer’s, 1 million suffering from Parkinson’s and another 500,000 patients suffering from other neurodegenerative diseases it is very important the find treatments and/or cures for these types of diseases.  As our population ages these numbers will likely increase since many of these types of neurodegenerative diseases affect the elderly in greater numbers than the young 

what is CBD ?

CBD stands for CANNABIDIOL – The most eminent naturally-occurring and most abundant non-psychoactive cannabinoid component found in cannabis that comprises up to 40% of the plant. The only most important cannabinoid ever discovered. It is commonly used as a dietary supplement to help support overall health. CBD is the most studied natural cannabinoid. According to many researchers, CBD may be the single most important cannabinoid ever discovered. The cannabis plant is a unique source of more than 70 structurally-related, plant-derived cannabinoids. Although one cannabinoid is known to have psychoactive effects associated with the use of illicit herbal cannabis, none of the other cannabinoids are known to cause intoxication. In recent decades, there have been major scientific advances that have led to the discovery of new plant-derived cannabinoids and a cannabinoid receptor system in the human body, or endocannabinoid system.  

WHAT IS ENDOCANNABINOID SYSTEM OR ECS?

CBD advantages to the human body are one of science’s newest and most exciting discoveries. ECS plays a fundamental role in the functioning of many of the major human physiological systems, including the nervous and immune systems. It regulates relaxation, eating, sleeping certain inflammation responses and even cognitive function. There are two types of cannabinoid receptors found throughout the body – CB1 and CB2. However, they are most abundant in the brain and immune system respectively. Our ECS is responsible for making sure that our body in functioning at an optimal level. ARE CBD AND THC THE SAME? NO-these are different compounds but they are both cannabinoids. THC is the cannabinoid that makes you high or stoned while CBD is not psychoactive unlike THC. It won’t get you “high”.  All products on this website contain less than .3% THC, therefore making it legal in all 50 U.S. States and many countries.

What causes CBD in fibromyalgia?

When someone uses the word soft tissue rheumatism, it actually means fibromyalgia or the fibromyalgia syndrome. The term is composed of the Latin word Fibra (fiber), as well as the Greek expressions Mys (muscle) and Algos (pain). He describes one of the most common symptoms that people suffering from the condition suffer from. The name of the disease was known to only a few people until a few years ago, but since the cannabis drug cannabidiol (CBD) enjoys so much public attention, the term fibromyalgia in the media is more common. Apparently, CBD has properties that may be useful for the treatment of the disease. How Can CBD Help With Fibromyalgia?   Does the appearance of the condition give reason to believe that CBD can help? People who suffer from fibromyalgia syndrome sometimes lose considerably in quality of life. Muscular pain in various parts of the body is associated with frequent fatigue and sleep disorders. Other symptoms may include decreased memory and concentration, depression, and a feeling of morning stiffness.   Fibromyalgia patients are also usually more sensitive to pain. Up to 80 percent of medical conditions affect women, most of them between 40 and 60 years old. A cause for fibromyalgia could not be determined so far. Today, it is assumed that several factors - ranging from predisposition to biological preconditions and psychological stress - all lead to the disease.   Established drug treatments for fibromyalgia do not exist, one resorts to sports and exercise rather than therapeutic measures. The use of CBD in fibromyalgia might be a useful adjunct to therapy in some patients.   What symptoms can be treated with cannabidiol? Since fibromyalgia is not associated with inflammation, the anti-inflammatory effect of CBD in fibromyalgia is not really significant. But CBD also has many other beneficial effects, some of which may be helpful in fibromyalgia syndrome.   As part of the treatment, many patients are also prescribed antidepressants. These are not always harmless with regard to their side effects and consequences. Also, CBD has properties that positively affect the mood and mood and increase well-being, but without causing serious side effects. Among other things, patients who use CBD in fibromyalgia report an increase in their agility.   The next issue that CBD can address is sleep problems because cannabinoid is known to both relax the mind and body and have a positive effect on sleep quality. The improved recovery and the relaxed state of mind generally improve the quality of life, and this promotes mild disease and mild symptoms.   Fibromyalgia and the endocannabinoid system Since the effect of CBD on fibromyalgia is poorly documented scientifically, and most of the information comes from patient reports, it is up to anyone to personally determine for themselves whether CBD will help or not.   Also, you should discuss this with the doctor, especially if you regularly take other medications. However, there are studies that associate fibromyalgia syndrome with a lack of endocannabinoids as a possible cause, and consider treatment with externally added cannabinoids as a potential treatment.   Another study showed that after use, fibromyalgia patients report reduced symptoms, better well-being and better mental health. For this reason, it is definitely worth trying CBD for fibromyalgia.   However, as reported by many users, only CBD products with a concentration of over 15% should be used. Low concentrations should be less helpful.   Source:  GLASMANN, Dieter Klaus. Was bewirkt CBD bei Fibromyalgie? Aug 8, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/was-bewirkt-cbd-bei-fibromyalgie/   source photo: https://pixabay.com/cs/

Pharmacokinetics and pharmacodynamics of cannabinoids

How do cannabinoids in the human body and what influence do they have on the organism? Pharmacologists have been dealing with this question for a long time. Already a few years ago, Dr. Franjo Grotenhermen summarized his thoughts on the subject in a scientific article.   Dr. Franjo Grotenhermen is a practicing physician and is considered an expert in the treatment of cannabis. This is not only shown by numerous scientific publications and book publications. The general practitioner is a highly respected speaker at various cannabis events, where he lectures on cannabis in medicine. In addition, he is an important part of the Working Group on Cannabis as Medicine (ACM). The working group offers interested parties the possibility of independent counseling and further education on the medical use of cannabis. At www.cannabis-med.org you can find information about cannabis in medicine, science, law and politics.   Pharmacokinetics and pharmacodynamics Pharmacokinetics is a branch of pharmacology that deals with the effects, distribution and metabolism of a consumed drug in the body as a function of time. This includes all processes that a substance undergoes in the body. Including the absorption of the active substance, distribution in the body, biochemical processing and excretion.   In contrast, pharmacodynamics deals with the influence of a drug on the organism or what biochemical and physiological effects it has on the body. The pharmacodynamic effects of a drug can be subdivided into desirable and undesired effects.   Cannabinoids In simple terms, cannabinoids interact with receptors of the endocannabinoid system (ECS), which are found in important organs, in the brain, the immune system or in the central nervous system, among other things. This affects the concentration of certain neurotransmitters in the ECS, which has a special effect.   Of particular interest for the pharmacological effect of cannabis is THC or delta (9) -tetrahydrocannabinol. In addition, the acidic metabolite THC-COOH, the non-psychoactive cannabidiol (CBD), several cannabinoid-like substances and newly discovered modulators of the body's cannabinoid system, which have promising potential for the therapeutic use of cannabis.   The effect of cannabinoids is mainly due to the activation of G-protein-coupled cannabinoid receptors in the brain and peripheral tissues. There are also indications of receptor-independent mechanisms. Usually, cannabinoids are dissolved and inhaled or cannabis products taken orally. Rectal use, sublingual or transdermal application, and eye drops as an application have only been studied in a few studies and are of little importance in today's practice.   The pharmacokinetics of THC vary depending on the mode of administration. In the case of pulmonary uptake of THC, the concentration of the active substance content in the blood plasma can be measured within minutes; psychotropic effects are noticeable within seconds to less minutes. They reach a maximum after 25-30 minutes and gradually decrease within 2-3 hours. When taken orally, the psychoactive effect begins after 30-90 minutes. It reaches its maximum after 2-3 hours and lasts about 4-12 hours depending on the dose and specific effects.   In doses that exceed the psychotropic threshold, cannabis intake usually results in increased well-being and relaxation with an intensified perception of common sensory experiences. The main acute side effects of overdose include anxiety and panic attacks, as well as physical symptoms such as increased heart rate and blood pressure changes.   It can not be ruled out that regular cannabis use can lead to mental dependency and mild withdrawal symptoms. Controversial are the occurrence and intensity of possible long-term harmful effects on psyche and perception, the immune system, fertility and pregnancy.   The indicators of medical use of cannabis include, but are not limited to, pain relief, muscle relaxation, immunosuppression, sedation, mood enhancement, appetite enhancement, intraocular pressure reduction, bronchodilation, neuroprotection and initiation of cancer cell death.   Source:  BOEDEFELD, Christian. Pharmakokinetik und Pharmakodynamik von Cannabinoiden.  Apr 19, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/pharmakokinetik-und-pharmakodynamik-von-cannabinoiden/     source photo: https://pixabay.com/cs/